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<blockquote data-quote="Old Man Jingles" data-source="post: 4623390" data-attributes="member: 18222"><a href="https://link.springer.com/article/10.1007/s12035-020-02093-z" target="_blank">Effects of Antimalarial Drugs on Neuroinflammation</a><a href="https://link.springer.com/article/10.1007/s12035-020-02093-z" target="_blank">Potential Use for Treatment of COVID-19-Related Neurologic Complications</a>Antimalarials have unique properties that distinguish them from other anti-inflammatory drugs. (A) They are very lipophilic, which enhances their ability to cross the blood-brain barrier (BBB). Hence, they have the potential to act not only in the periphery but also in the CNS, and could be a useful addition to our limited armamentarium against the SARS-CoV-2 virus. (B) They are non-selective inhibitors of phospholipase A2 isoforms, including cytosolic phospholipase A2 (cPLA2). The latter is not only activated by cytokines but itself generates arachidonic acid, which is metabolized by cyclooxygenase (COX) to pro-inflammatory eicosanoids. Free radicals are produced in this process, which can lead to oxidative damage to the Central Nervous System.</blockquote>

[QUOTE="Old Man Jingles, post: 4623390, member: 18222"] [URL='https://link.springer.com/article/10.1007/s12035-020-02093-z'][SIZE=7][B]Effects of Antimalarial Drugs on Neuroinflammation Potential Use for Treatment of COVID-19-Related Neurologic Complications[/B][/SIZE][/URL] Antimalarials have unique properties that distinguish them from other anti-inflammatory drugs. (A) They are very lipophilic, which enhances their ability to cross the blood-brain barrier (BBB). Hence, they have the potential to act not only in the periphery but also in the CNS, and could be a useful addition to our limited armamentarium against the SARS-CoV-2 virus. (B) They are non-selective inhibitors of phospholipase A2 isoforms, including cytosolic phospholipase A2 (cPLA2). The latter is not only activated by cytokines but itself generates arachidonic acid, which is metabolized by cyclooxygenase (COX) to pro-inflammatory eicosanoids. Free radicals are produced in this process, which can lead to oxidative damage to the Central Nervous System. [/QUOTE]

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