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Ivermectin Is a COVID 'Wonder Drug'
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<blockquote data-quote="Sportello" data-source="post: 4732496" data-attributes="member: 55299"><p>[URL unfurl="true"]https://www.covid19treatmentguidelines.nih.gov/antiviral-therapy/ivermectin/[/URL]</p><p></p><h2><em>Recommendation</em></h2><p></p><ul> <li data-xf-list-type="ul"><em>The COVID-19 Treatment Guidelines Panel <strong>recommends against</strong> the use of <strong>ivermectin</strong> for the treatment of COVID-19, except in a clinical trial <strong>(AIII)</strong>.</em></li> </ul><p></p><h2><em>Rationale</em></h2><p><em></em></p><p><em>Ivermectin has been shown to inhibit the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in cell cultures.7 However, pharmacokinetic and pharmacodynamic studies suggest that achieving the plasma concentrations necessary for the antiviral efficacy detected in vitro would require administration of doses up to 100-fold higher than those approved for use in humans.8,9 Even though ivermectin appears to accumulate in the lung tissue, predicted systemic plasma and lung tissue concentrations are much lower than 2 µM, the half-maximal inhibitory concentration (IC50) against SARS-CoV-2 in vitro.10,11</em></p><p><em></em></p><p><em></em></p><p><em>Ivermectin is not approved for the treatment of any viral infection, including SARS-CoV-2 infection. The FDA issued a <a href="https://www.fda.gov/animal-veterinary/product-safety-information/fda-letter-stakeholders-do-not-use-ivermectin-intended-animals-treatment-covid-19-humans" target="_blank">warning</a> in April 2020 that ivermectin intended for use in animals should not be used to treat COVID-19 in humans.</em></p></blockquote><p></p>
[QUOTE="Sportello, post: 4732496, member: 55299"] [URL unfurl="true"]https://www.covid19treatmentguidelines.nih.gov/antiviral-therapy/ivermectin/[/URL] [HEADING=1][I]Recommendation[/I][/HEADING] [I][/I] [LIST] [*][I]The COVID-19 Treatment Guidelines Panel [B]recommends against[/B] the use of [B]ivermectin[/B] for the treatment of COVID-19, except in a clinical trial [B](AIII)[/B].[/I] [/LIST] [I][/I] [HEADING=1][I]Rationale[/I][/HEADING] [I] Ivermectin has been shown to inhibit the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in cell cultures.7 However, pharmacokinetic and pharmacodynamic studies suggest that achieving the plasma concentrations necessary for the antiviral efficacy detected in vitro would require administration of doses up to 100-fold higher than those approved for use in humans.8,9 Even though ivermectin appears to accumulate in the lung tissue, predicted systemic plasma and lung tissue concentrations are much lower than 2 µM, the half-maximal inhibitory concentration (IC50) against SARS-CoV-2 in vitro.10,11 Ivermectin is not approved for the treatment of any viral infection, including SARS-CoV-2 infection. The FDA issued a [URL='https://www.fda.gov/animal-veterinary/product-safety-information/fda-letter-stakeholders-do-not-use-ivermectin-intended-animals-treatment-covid-19-humans']warning[/URL] in April 2020 that ivermectin intended for use in animals should not be used to treat COVID-19 in humans.[/I] [/QUOTE]
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