German airspace has been re-opened by the Federal Government on a basis of
special permits. Lufthansa, Air Berlin, smaller scheduled airlines as well as air cargo carriers have started up their operations. Cologne airport as such is open. See also
http://www.radarvirtuel.com/#. Other air spaces (France etc.) are also open, so trans-atlantic traffic can resume (and has been resumed). From another forum I got the info that cargo for up to 11 MD-11F has been stacked in Cologne.
Madrid is connect by major highways to France and further North. High-speed rail connections (Talgo express) are available up into Geneva and Zuerich. The French Postal service even has its own TGV high-speed night trains.
See also another article
http://www.spiegel.de/international/business/0,1518,534978,00.html
There are opportunities and lessons to be learned when thinking outside the (brown) box for smarter solutions.