I was in the same boat a few years ago. I struggled to scratch even once until the very end, maxed out my hours several days in a row from driving around in circles trying to find one or two addresses, ready to crash the package car into a tree and just walk away.
Just be patient and calm and acknowledge that you're going to have really, -really- crappy days. A whole bunch of them. Don't quit, don't be afraid to ask for help, and sooner or later you'll just 'get it' and be able to go blind on any route. Nobody can really say what 'getting it' means, since it could be any one of a dozen hurdles holding you up.
One practical piece of advice I can give is a step beyond what others have recommended: once you have your map, copy as much of the area as you can fit on a note card, or a sheet of paper all folded up. Don't trace or photocopy, draw that thing by hand. Mark all the streets, appropriate street numberings, draw little boxes for the major business stops, etc. Keep that in your shirt pocket, laminated if possible. Not only is it easier to pull out in a hurry to remember where you are, but the act of creating it yourself etches the area knowledge into your memory.
More is coming to mind...
Try to organize as you go. If you're digging on the floor for one package, instead of flipping things over and tossing them aside to get to that little bitty one underneath, pick them up and put them in the correct place so you're not doing the same dig-around all over again. If your shelf is loosening up and you have some space to move stuff around, get everything on that shelf in order. If nothing more fits on your shelf, scoot all the big stuff on the floor underneath its proper location, and then -don't hit curbs-.
If you do hit a curb, don't freak out. Stop and reload everything you can. Even if it takes ten minutes, it'll be less time than all the delays you'll experience trying to find that tiny 3000 that fell, slid to the back, and got buried under your 7000s.
Be well organized beforehand. Look through EDD and see if you have easy business stops like offices or small retail stores that are getting air and ground separately. You might even have resis like this. find the ground and load it next to the air, and bring it all in at once. Deliver them as two stops so you're not losing credit, and now you don't have to go back later, and you've bought a few minutes.
And most of all, again, stay calm. Even when you 'get it' you'll still be expected to move impossibly fast without compromising safety, do more work in less time, meet the conflicting demands of different customers without upsetting anyone, break the rules to make your sups look good without breaking any rules and getting fired.