I prefer a route where I deal with the same, predictable people and problems every day, and where I can run a personal errand during lunch. For me, the worst route is a military installation with lots of civilian, federal employees.
People say that towns and cities are full of difficult, pain in the ass, crazy people. But I'd rather deal with ten 'town' problems than one 'rural' problem.
I live in California. I didn't mean to make it seem that wild dogs are a big problem in rural areas. But they do happen from time to time.
Dogs are very Jekyll & Hyde when they get into a group. They quickly establish an efficient hierarchy and can be very unpredictable.
All it takes is a few ordinarily well-behaved ranch or farm dogs to find each-other, and the next thing you know they are mauling livestock. Or anything in their path. Just look for the sheep, pig, or goat with no nose, lips, ears, or tail.